Antiperspirant and Antibacterial Activities of Curcuma xanthorrhiza Extract as a Potential Alternative Treatment for Hyperhidrosis

Hyperhidrosis is a condition characterized by excessive sweating that affects at least 5% of the world’s population. It normally associated with unpleasant body odour which requires continuous maintenance throughout life. Antiperspirants and deodorants are first-line treatments for hyperhidrosis. However, association this class product risk other diseases has increased search an effective antiperspirant from natural sources. This study aimed to investigate antibacterial activities Curcuma xanthorrhiza Roxb. Using in vitro microbial assay against specific bacteria responsible rat foot pad analysis. Quality control fractionated extract was conducted using reversed-phase HPLC based on two active markers: curcumin. Toxicity tests were OECD guidelines (50–2000 mg/kg). Inhibition zone, MIC, MBC values hexane fraction C. showed equivalent activity positive (p > 0.05). No swelling, redness, or rashes observed injection area study. Treatment 40, 80, 160 mg/kg significantly decreased sweat excretion up 79.34% < 0.05) after 15 min compared negative control. Histopathology analysis reduced size secretory units plantar glands post treatment In conclusion, able reduce model inhibit growth causing odour.